Detailed view for LOAG_01625

Basic information

TDR Targets ID: 947530
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 7.6264 | Length (AA): 1875 | MW (Da): 210969 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF00387   Phosphatidylinositol-specific phospholipase C, Y domain
PF00388   Phosphatidylinositol-specific phospholipase C, X domain
PF00617   RasGEF domain
PF00788   Ras association (RalGDS/AF-6) domain
PF09279   Phosphoinositide-specific phospholipase C, efhand-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0005085   guanyl-nucleotide exchange factor activity  
GO:0004435   phosphoinositide phospholipase C activity  
GO:0008081   phosphoric diester hydrolase activity  
GO:0007264   small GTPase mediated signal transduction  
GO:0007165   signal transduction  
GO:0006629   lipid metabolic process  

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
67 243 2byv (E) 753 922 19.00 0 0.98 0.3905 -1.02
69 321 4l9m (A) 206 465 27.00 0.00000065 1 0.411733 -0.48
69 243 3qxl (A) 51 219 28.00 0.00000053 1 0.462133 -1.1
138 257 5cm8 (A) 327 451 30.00 0.03 0.88 0.2528 -0.02
631 1521 4qj3 (B) 32 866 30.00 0 1 0.4283 1.01
834 1495 2fju (B) 227 794 44.00 0 1 0.343867 0.88
1383 1473 2uzp (A) 174 269 23.00 0 0.2 0.201633 0.03
1383 1499 3jzy (A) 1544 1661 15.00 0 0.6 0.1945 -0.58
1546 1648 1wxa (A) 11 112 20.00 0 0.96 0.292033 -0.49
1675 1855 4uos (A) 3 184 9.00 0.0015 0.01 0.307733 -1.46
1719 1854 2byf (A) 1 116 38.00 0.05 0.52 0.205733 0.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_135011)

Species Accession Gene Product
Brugia malayi Bm1_40155   phospholipase C homolog
Brugia malayi Bm1_40160   phospholipase C homolog
Caenorhabditis elegans CELE_F31B12.1   Protein PLC-1, isoform C
Homo sapiens ENSG00000138193   phospholipase C, epsilon 1
Loa Loa (eye worm) LOAG_01625   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000024998   phospholipase C, epsilon 1
Schmidtea mediterranea mk4.002805.06  
Schmidtea mediterranea mk4.002771.01  
Schmidtea mediterranea mk4.002771.00  

Essentiality

LOAG_01625 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F31B12.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0058 0.5 0.5
0.005 0.2612 0.9039
0.0107 0.5 0.5
0.0125 0.3893 0.3893
0.0109 0.4866 1
0.0072 0.2639 0.9142
0.0018 0.5 0.5
0.0071 0.2549 1
0.0057 0.3491 0.3491
0.0121 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_01625 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment